A Medical-Based drama centered around Meredith Grey, an aspiring surgeon and daughter of one of the best surgeons, Dr. Ellis Grey. Throughout the series, Meredith goes through professional and personal challenges along with fellow surgeons at Seattle Grace Hospital.

Barowner Joe collapses in his bar and needs to undergo an $200,000 surgery to survive. Since Joe has no insurance George tries to find a way to get the money together. Dr. Webber is recovering from his operation and appointed Burke as his replacement. Burke has now to face the consequences that come with the responsibilities of his new position. The return of his wife Addison puts an end to Derek's relationship with Meredith. Meredith herself is more concerned with the pregnancy of Christina and her secret relationship with Burke. Written by SSS

After a fatal car accident, a man, a woman and their son are patients in the Seattle Grace hospital. The injuries of the mother reveal a family secret. Another patient has swallowed something strange, but refuses to reveal what. On the personal level, Meredith and Cristina try to get along with the ending of their relationships. While Meredith tries to avoid Shepherd, Cristina and Burke are involved in the same medical cases. George feels uncomfortable still working with Olivia, who wants him to forgive her. Written by SSS

Meredith's mother is admitted to the hospital, revealing that the once great surgeon now has Alzheimer's disease. Meanwhile, Christina faints during an operation and needs immediate care. She loses her baby due to complications and becomes a patient. Burke finally finds out about her pregnancy when it's too late. Mrs. Grey gives hell to George because she thinks he is her husband but George copes with it. Written by Anonymous

Meredith deals with her mother's illness and with her complicated relationship with the Shepherds. There is still hope for Addison and Derek, because he didn't sign the divorce papers, but he himself does not know what to do. Meanwhile, Burke and Cristina also deal with their relationship, and Izzie and Alex go on a date. But Alex is nervous because he might lose his M.D., so he does not act as himself. Written by Anonymous

A storm rages in Seattle. Izzie is very disappointed by her date with Alex, and Meredith is upset with Derek. They both complain to George, which drives him crazy. At the hospital, Cristina is assigned a patient who uses porn as a pain killer, and Meredith takes care of an Asian girl who needs to see a Shaman before surgery. There is a power shortage, and George and Alex are stuck in an elevator with a critical patient. They need to perform heart surgery, but Alex is too freaked out, so George does it. Written by Anonymous

A train wreck brings in multiple casualties, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his mojo a disheartening experience, and Cristina searches high and low for a missing appendage.

Addison and Derek go to marriage counseling. Derek says that he's finished with Meredith. Meanwhile, Meredith becomes the main gossip topic in the hospital and Izzie and Christina discover a pregnant man. Preston tells the Chief about him and Christina and Alex finally kisses Izzie. Written by Anonymous

Friends of Derek and Addison come from New York for a preventative surgery that causes discord among both couples. Meanwhile, George helps a man who has fallen from a roof, and Bailey delivers news to the Chief.

Thanksgiving sends the occupants of Meredith's house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner to which it appears no one is coming.

Meredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem. Meanwhile, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.

The mother of the quints blames herself. Meanwhile, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina takes care of an inmate desperate to stay at the hospital.

Christmas hits Seattle, with Izzie caring for a man who fell from his roof while hanging decorations. Meanwhile, Cristina helps perform a heart transplant on a depressed boy, and George has to contend with the family from Hell.

Izzie becomes attracted to a male patient with a heart condition, and George treats Bex, an intersex patient. Meanwhile, Meredith's mother receives a visitor, and Derek and Addison's relationship is still rocky.

Meredith must choose between her dog and her roommates. Meanwhile, George deals with an elderly patient who has outstayed her welcome, Bailey's pregnancy has complications, Alex gets his exam results, and Richard has a strike on his hands.

The nurses strike, leaving the doctors unprepared for their extra duties. Cristina and Burke have to define their work relationship, Izzie relates to a pregnant teenager, and Meredith finds parallels to her mother in a case requiring her to remove life support. Written by layle

The lives of everyone in the OR are threatened when a patient enters with a bomb inside him, and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.

While the man with the bomb lodged in his chest remains in Burke's OR with Meredith's hand in the cavity, Bailey's injured husband remains in Derek's. Meanwhile, Bailey's distress puts her unborn baby at risk.

Derek and Addison are shaken by the arrival of a figure from their past. Meanwhile, Burke learns Cristina's secret, Izzie deals with a very unusual case, Meredith delves into her family's dirty laundry, and George pours his heart out.

Meredith and George face the consequences of their actions, Izzie gets closer to Denny, who has been readmitted, and Addison asks for Bailey's help with an embarrassing ailment.

Cristina babysits for Bailey and does not take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, George connects with Callie, and Denny continues to come between Alex and Izzie.

Superstition strikes, with the interns convinced a series of deaths will occur. A complication from the LVAD surgery puts Denny in the OR, Cristina plans to make George move out, and Richard's old AA sponsor is admitted for treatment.

George begins to overstay his welcome at Burke and Cristina's apartment. Cristina takes a seminar and discovers that Chief Webber is taking it too. Meanwhile, Meredith learns a startling secret about her father, Bailey worries her colleagues will not treat her the same now that she is a mother, and Alex gets a lesson in bedside manners. Written by Alex

While Izzie grills George about the personal details of his life, Addison takes Alex to task about a sensitive case. Also, Burke feels the pressure when he treats his musical hero, and Meredith considers dating a hunky vet. Written by Alex

Derek lets his emotions run away from him, and Burke and Izzie make a new suggestion to Denny. Meanwhile, the interns treat a family involved in an auto accident, Callie makes Meredith and Izzie uncomfortable, and Addison strikes back at Alex. Written by Alex

George works a case with Derek, while Meredith works with Callie. Meanwhile, Finn gives an update on Doc's health, and Burke and Izzie keep looking for a heart for Denny. Written by Alex

Burke is admitted as a patient, along with Richard's niece. Izzie and the others fight to keep Denny alive, while Alex tries to secure the donor heart for him.

Richard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.